Searchable, peer-reviewed, open-access proceedings from bioscience and biomedical conferences

bp0002rdr2 | Maternal Recognition of Pregnancy | REDR1990

Molecular biology of trophoblast interferons and studies of their effects in vivo

Flint APF , Parkinson TJ , Stewart HJ , Vallet JL , Lamming GE

Summary. Southern blotting of bovine genomic DNA indicated the presence of at least 3 bovine tIFN genes. The full DNA sequence of one of these genes, thought to be expressed in trophoblast, has been determined, including 193 bp of 5' non-coding region. The inferred amino acid sequence of bovine tIFN is more similar to ovine tIFN (80%) than to bovine IFN-αII (70%). The 5' flanking sequence has some similarity with bovine IFN-&#94...